Most drugs are weak organic acids or bases, existing in un-ionized and ionized forms in an aqueous environment. The un-ionized form is usually lipid soluble (lipophilic) and diffuses readily across cell membranes.

The solubility of a gas decreases with increasing temperature. Henry’s law describes the relationship between the pressure and the solubility of a gas.

Solubility is based on the highest-dose strength of an immediate release product. A drug is considered highly soluble when the highest dose strength is soluble in 250 mL or less of aqueous media over the pH range of 1 to 7.5.

Swallowing a drug is a relatively slow method of taking a drug. After the drug is swallowed, it is dissolved in the stomach and then absorbed into the bloodstream from the linings of the stomach and later, the small intestine.

Lipid solubility is an important and desired feature of most administered drugs that allows for the passive diffusion across cellular membranes. Lipophilic drugs are also difficult to excrete.

Solubility of lipids in solvents is based on the relative proportion of polar and non-polar groups in the matrix. The solubility of these lipids increase in alcoholic solvents as the carbon chain length of the alcohol increases, so they are more soluble in ethanol and n-butanol.

Snacking on protein-rich foods like eggs before drinking alcohol can help slow the emptying of your stomach and delay alcohol absorption ( 2 , 3 ). Plus, protein is the most filling macronutrient, keeping you feeling fuller for longer, which can reduce your risk of alcohol-induced food binges later in the night ( 4 ).

70% of 50 is 35, so in the first solution you have 35ml of alcohol. If you combine a liquid that has 70% alcohol and a liquid that has 50% alcohol half and half you would get a liquid that has 60% alcohol. They do not add up. They get mixed.