You may need dose adjustments or special tests in order to safely take both medications together. This combination may affect seizure control and cause drowsiness. You should avoid driving until you know how these medications will affect you.

Some products that may interact with this drug include: clozapine, fluvoxamine, orlistat, sodium oxybate. The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is taken with other products that may also cause drowsiness or breathing problems.

Taking certain antidepressants with diazepam can increase your risk for drowsiness or sleepiness. It can also cause your breathing to slow down or stop.

This medicine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these side effects, tell your doctor right away.

Zonisamide is used in combination with other medications to treat certain types of seizures. Zonisamide is in a class of medications called anticonvulsants. It works by decreasing abnormal electrical activity in the brain.

Zonisamide is administered by mouth, as an oral capsule, or it may be compounded into an oral liquid. This medication may be given with or without food, however, if your pet vomits or acts sick after receiving it, give this medication with food or a small treat. The medication should begin working within 1-2 days.

Results. Zonisamide mainly in a high acute dose impaired the spatial memory, whereas when administered repeatedly, its effect was observed only in the initial phase of the study. Emotional memory disturbances were noted only during repeated administration of zonisamide.

Do not stop taking zonisamide without first checking with your doctor. Stopping the medicine suddenly may cause your seizures to return or to occur more often. Your doctor may want you to gradually reduce the amount of medicine you are taking before stopping it completely.

Do not stop using zonisamide suddenly, even if you feel fine. Stopping suddenly may cause increased seizures. Follow your doctor’s instructions about tapering your dose. Do not share this medicine with another person, even if they have the same symptoms you have.

Report any new or worsening symptoms to your doctor, such as: sudden mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), depressed, or have thoughts about suicide or hurting yourself.

The most common side effects of zonisamide capsules include: drowsiness. loss of appetite. dizziness.

Results from this pilot and open naturalistic study suggest that zonisamide may effectively augment response to anxiolytic medications in patients with treatment refractory anxiety. Larger and controlled studies are warranted to confirm these preliminary findings.

Longitudinal assessment indicated that zonisamide was associated with a significantly slower rate of BMI and weight increases compared with placebo (P = . 01). No patients in the zonisamide group experienced significant weight gain, compared with 33% of placebo-treated patients (P = . 009).

HAIR LOSS with Zonegran!! Doctor Says There’s No Such Side Effect | Epilepsy Foundation.

Some side effects of zonisamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine.

Phenytoin, carbamazepine, phenobarbital, lamotrigine, oxcarbazepine, felbamate, and zonisamide have been implicated. The pathogenic mechanisms of AHS are incompletely understood. Several clinical reports have documented the effects of antiepileptic drugs (AEDs) on the immune system.

Conclusion: Our results indicated that zonisamide is as effective as topiramate in migraine prophylaxis and can be considered as an alternative treatment when topiramate is not tolerated well.

Studies have shown that Topamax may also speed up metabolism, which means that the body burns calories more quickly. Clinical trials have shown that about 6%-17% of people who take Topamax will experience weight loss, and while many people may see this as an added benefit, losing too much weight isn’t a good thing.

To date, there are no known problems associated with long term use of topiramate. It is a safe and effective medication when used as directed.