Q. How do you administer Nexium IV?
The recommended adult dose is either 20 mg or 40 mg NEXIUM given once daily by intravenous injection (no less than 3 minutes) or intravenous infusion (10 minutes to 30 minutes).
Q. How do you give a NEXIUM injection?
2.5 ml or half of the reconstituted solution (8 mg/ml) should be given as an intravenous injection over a period of at least 3 minutes. Any unused solution should be discarded. 1.25 ml of the reconstituted solution (8 mg/ml) should be given as an intravenous injection over a period of at least 3 minutes.
Q. How do you dilute NEXIUM infusion?
The continuous infusion is prepared by using two 40 mg vials. Reconstitute each 40 mg vial with 5 mL each of 0.9% Sodium Chloride Injection, USP. The contents of the two vials should be further diluted in 100 mL 0.9% Sodium Chloride Injection, USP for intravenous use.
Q. What medications Cannot be taken with NEXIUM?
DRUG INTERACTIONS Esomeprazole (Nexium) can interact with many drugs, vitamins and herbal supplements. Common medications that should not be taken at the same time as esomeprazole (Nexium) include clopidogrel (Plavix), St. John’s Wort, rifampin (Rifadin), and methotrexate.
Q. What is the contraindications for Nexium?
NEXIUM is contraindicated in patients with known hypersensitivity to substituted benzimidazoles or to any component of the formulation. Hypersensitivity reactions may include anaphylaxis, anaphylactic shock, angioedema, bronchospasm, acute interstitial nephritis, and urticaria [see Adverse Reactions (6)].
Q. Which PPIs can be given IV?
Currently, three IV PPIs are available in the US (esomeprazole, pantoprazole and lanzoprazole). IV omeprazole is available in Europe and Asia.
Q. What is the contraindications for NEXIUM?
Q. Does Nexium interfere with blood pressure medications?
It depends on the medication you are taking to treat high blood pressure and cholesterol. For example, taking a diuretic can be impacted if you also take Nexium. I recommend discussing with your physician or pharmacist to make sure there are no drug interactions of concern if you combine the medications.
Q. What does Nexium interact with?
Some products that may interact with this drug include: cilostazol, clopidogrel, methotrexate (especially high-dose treatment), rifampin, St John’s wort. Some products need stomach acid so that the body can absorb them properly.
Q. Who shouldnt take Nexium?
People who have an allergy to any other PPI should not take Nexium. These precautions and any questions about Nexium and other PPIs should be discussed with a medical professional. Proton pump inhibitors like Nexium have been involved in over 12,000 lawsuits.
Q. Can proton pump inhibitors be given IV?
Intravenous (IV) administration of a proton pump inhibitor (PPI) is a faster way to achieve gastric acid suppression than oral administration of the same agent. Peak suppression after IV administration occurs within hours, compared with several days later after oral administration.
Q. When is a PPI contraindicated?
CONTRAINDICATIONS / PRECAUTIONS. Lansoprazole is contraindicated in patients who have shown lansoprazole hypersensitivity. Lansoprazole is a proton pump inhibitor (PPI) and should be used with caution in patients with known proton pump inhibitors (PPIs) hypersensitivity.
Q. When to use Nexium for injection and infusion?
Nexium for injection and infusion is indicated in adults for: • Gastric antisecretory treatment when the oral route is not possible, such as: – gastroesophageal reflux disease (GERD) in patients with esophagitis and/or severe symptoms of reflux. – healing of gastric ulcers associated with NSAID therapy.
Q. Do you need to mix Nexium i.v.with liquid?
You may need to mix Nexium I.V. with a liquid (diluent) in an IV bag. When using injections by yourself, be sure you understand how to properly mix and store the medicine. Read and carefully follow any Instructions for Use provided with your medicine.
Q. Is it safe to take Nexium i.v.for Gerd?
Safety and efficacy of NEXIUM I.V. for Injection as a treatment of GERD patients with a history of erosive esophagitis for more than 10 days have not been demonstrated.
Q. How often should I take Nexium for erosive esophagitis?
Adult Patients The recommended adult dose is either 20 mg or 40 mg NEXIUM given once daily by intravenous injection (no less than 3 minutes) or intravenous infusion (10 minutes to 30 minutes). Safety and efficacy of NEXIUM I.V. for Injection as a treatment of GERD patients with erosive esophagitis for more than 10 days have not been demonstrated.
