Jason Momoa was unable to play his role as Khal Drogo in Game of Thrones until the show decided to recast Daenerys Targaryen with Emilia Clarke.
Game of Thrones star Emilia Clarke refuses to watch House of the Dragon
Game of Thrones got off to a rough start with the infamous scrapped pilot episode, where everything seemed to have gone wrong, from the plot to the casting. Even Jason Momoa felt like he wasn't really present until they replaced the actress who plays Daenerys Targaryen.
Along with the rework came the modification of some key details that upset author George RR Martin. He didn't like what they had done with the intimate scene between Daenerys and Khal Drogo.
In the original version of the pilot episode of Game of Thrones, Daenerys Targaryen was played by actress Tamzin Merchant. When they shot the intimate scene after her wedding to Jason Momoa's Khal Drogo, she wasn't actually assaulted, but it was a consensual act. Also in George RR Martin's novel the same followed.