Pepsin is a stomach enzyme that serves to digest proteins found in ingested food. Gastric chief cells secrete pepsin as an inactive zymogen called pepsinogen. Parietal cells within the stomach lining secrete hydrochloric acid that lowers the pH of the stomach.

Pepsin is a chain protein (monomer) composed of two similar folding domains separated by a deep cleft. The catalytic site of pepsin is formed at the junction of the domain, each domain contains two aspartic acid residues, Asp32 and Asp215.

gastric juice

If pepsin got mutated, then the stomach wouldn’t be able to properly digest the food. This would cause the person to have bloating, heartburn, and stomach pains.

Also avoiding carbonated beverages, tomato-based products, citrus products, spicy foods, chocolate, breath mints, coffee, caffeinated beverages and alcohol reduces the activation of pepsin. I recommend drinking alkaline water with a pH greater than 9.5 to reduce the activation of the pepsin enzyme in the stomach.

Typically used in conjunction with HCl, pepsin is considered very safe when administered to assist digestion. Digestive enzymes help to break down food proteins.

Conclusions: Unlike conventional drinking water, pH 8.8 alkaline water instantly denatures pepsin, rendering it permanently inactive. In addition, it has good acid-buffering capacity. Thus, the consumption of alkaline water may have therapeutic benefits for patients with reflux disease.

How is laryngopharyngeal reflux treated?

1. Follow a bland diet (low acid levels, low in fat, not spicy).
2. Eat frequent, small meals.
3. Lose weight.
4. Avoid the use of alcohol, tobacco and caffeine.
5. Do not eat food less than 2 hours before bedtime.
6. Raise the head of your bed before sleeping.
7. Avoid clearing your throat.

You can sip on tea to help prevent digestive issues and to get quick relief. Teas aren’t just soothing and warm beverages. They are powerful and active botanicals that can be extremely effective at taming tummy troubles. These teas are my go-to remedies for gas, bloating, nausea, acid reflux and LPR.

Ginger can reduce the likelihood of stomach acid flowing up into the esophagus. Ginger can also reduce inflammation. This may relieve symptoms of acid reflux.

Herbal tea Mint triggers acid reflux for many. Chamomile, licorice, slippery elm, and marshmallow may make better herbal remedies to soothe GERD symptoms. Licorice helps increase the mucus coating of the esophageal lining, which helps calm the effects of stomach acid.

Fasting results in a nonsignificant increase in laryngopharyngeal reflux disease. The increase can be hypothetically explained on the change in eating habits and the known alterations in gastric secretions during Ramadan.

When mucus starts to build up or trickle down the back of the throat, the medical name for this is postnasal drip. Causes of postnasal drip include infections, allergies, and acid reflux. A person may also notice additional symptoms, such as: a sore throat.

Patients with suspected LPR frequently may present impaired ocular function and symptoms. In particular, patients with suspected LPR show a significant association between severity of digestive symptoms and ocular complaints.

Even moderate stress can dramatically increase the amount of reflux. Performers should be aware that: the act of strenuous voicing exercises may cause an increase in reflux. In addition, overworked vocal folds will not handle the effects of reflux as well as when rested.