Abstract. The akinetic crisis is an “off” state that lasts more than 48 hours with akinesia, rigidity and bradykinesia, occurring with signs of CNS dysregulation in advanced stages of Parkinson’s disease. 7 akinetic crises lasting 4 to 14 days (average 9.3) were observed in 744 hospitalizations over a period of 7 years …

Akinesia is a term for the loss of ability to move your muscles voluntarily. It’s most often described as a symptom of Parkinson’s disease (PD). It can appear as a symptom of other conditions, too.

The akinetic–rigid syndromes are defined by paucity and slowness of movement accompanied by muscle stiffness and resistance to passive movement. The akinetic–rigid syndrome is typical of idiopathic Parkinson’s disease, so is often described as the syndrome of parkinsonism.

PD has spontaneous “exacerbations.” Another common assumption is that PD can “flare up” unexpectedly. But PD does not work this way. Although symptoms may fluctuate throughout the day, the progression of PD is very slow. If PD symptoms worsen over days or weeks, then it is critical to search for an underlying cause.

Probably the most disabling symptom of Parkinson’s is a general lack or slowness of voluntary movements. This is called akinesia and is often seen in association with the rigidity or stiffness of the muscles.

Approximately 80% of akinetic-rigid syndromes are due to Parkinson’s disease. Treatment of Parkinson’s disease should be determined by level of disability and handicap. The combination of levodopa and peripheral dopadecarboxylase inhibitor is the most efficacious symptomatic treatment for Parkinson’s disease.

Akinetic: Related to the loss of the normal ability to move the muscles.

Akinesia is the absence of movement. A person with akinesia cannot move their muscles, even if they try. A person with dyskinesia or difficulty in movement has muscles that move involuntarily and unexpectedly. Examples can include tremors or shaking or spastic movements, which can appear like sudden jerking movements.

Akinesia is the absence of movement while hypokinesia describes abnormally decreased movement. Bradykinesia refers to slowness of movement. Akinesia, hypokinesia and bradykinesia are cardinal features of extrapyramidal disease, to the extent that some neurologists refer to parkinsonism as an akinetic–rigid syndrome.

Akinetic crisis in PD appears to be associated with a particularly severe loss of presynaptic striatal dopamine function that does not improve after recovery. Apart from presynaptic dopaminergic function, other dopaminergic or nondopaminergic mechanisms are involved in the clinical improvement of motor functions after akinetic crisis in PD.

This article reviews literature on three emergencies in Parkinson’s disease (PD): Akinetic crisis, severe dyskinesias or life-threatening dyskinesias, and polyneuropathy during duodenal L-Dopa gel infusion treatment. Akinetic crisis is also known as Parkinsonian hyperpyrexia, Neuroleptic-like malign …

Akinetic crisis is also known as Parkinsonian hyperpyrexia, Neuroleptic-like malignant syndrome, Acute akinesia, and Malignant syndrome in parkinsonism.

The clinical picture is similar to that of neuroleptic malignant syndrome, and the condition has also been termed as neuroleptic malignant-like syndrome, malignant syndrome or parkinsonism-hyperpyrexia [3].