Weakly electrolytes and nonpolar molecules frequently have poor water solubility. Their solubility usually can be increased by the addition of water miscible solvent in which the drug has good solubility. This process is known as cosolvency, and the solvents used to increase solubility are known as cosolvent.

A cosolvent is a substance that is added to a mixture of two or more separate substances that are typically immiscible, in order to make them mixable. Cosolvents are added to increase the solvent power of the primary substance in the mixture.

Cosolvents improve solubility between non-miscible phases, as demonstrated by a solute dissolved in organic solvent but insoluble in water (left). A cosolvent miscible in both phases and able to dissolve the solute is added to form a homogeneous solution of water, organic solvent, and compound (right).

Answer: Common cosolvents for this purpose are ethanol, propylene glycol, glycerine, glycofural, and polyethylene glycols.

This process is known as cosolvency, and the solvents used to increase solubility are known as cosolvent. Cosolvent system works by reducing the interfacial tension between the aqueous solution and hydrophobic solute. It is also commonly referred to as solvent blending.

These results demonstrate that the strong water/cosolvent (water–ethanol) attraction is the key. Because of the strong water–cosolvent attraction, the total number of hydrogen bonding with PDEA is decreasing.

A co solvent system is one in which a water miscible or partially miscible organic solvent is mixed with water to form a modified aqueous solution. The resulting solution will have physical properties that are intermediate to that of the pure organic solvent and water through the reduction of water–water interaction.

Co-solvent solubilization approach has been used to enhance the solubility of seven antidiabetic drugs: gliclazide, glyburide, glipizide, glimepiride, repaglinide, pioglitazone, and roziglitazone.

Acetone, ethanol, and methanol were selected as cosolvents. Optimal nanoparticles were achieved with ethanol as a cosolvent, and the formation efficiency of the particles was also higher with ethanol as compared with acetone or methanol.

It has been demonstrated that cyclodextrins can be used as complexing agents for poorly soluble anti-cancer drugs, increasing their solubility and hence drug availability.

The results of the study show that ethanol has a role as a cosolvent where the OH (hydroxyl) as the head (polar) is attached to the polar methanol molecule while the CH (hydrocarbon) group as the tail (non-polar) interacts with the non-polar gasoline molecule.

Glycerol is a co-solvent for water extraction that has been shown to be highly effective for obtaining polyphenol extracts under atmospheric conditions.

Cosolvents improve solubility between non-miscible phases, as demonstrated by a solute dissolved in organic solvent but insoluble in water (left). A cosolvent miscible in both phases and able to dissolve the solute is added to form a homogeneous solution of water, organic solvent, and compound (right).

The effect of cosolvency on drug solubilization can be great, as evidenced by a 2009 study in which researchers from Panjab University showed the solubility of various anti-diabetic drugs increase by more than 500 times by use of a cosolvent.

A cosolvent miscible in both phases and able to dissolve the solute is added to form a homogeneous solution of water, organic solvent, and compound (right). In chemistry, cosolvents are substances added to a primary solvent in small amounts to increase the solubility of a poorly-soluble compound.

The effectiveness of a cosolvent is determined by its solubilization power. This is the maximum rate of dissolution of a solute in mixtures of various compositions. Cosolvents work best in the presence of another solvent that, in conjunction, enhances the dissolution of a solute.