Cyclobenzaprine works by blocking nerve impulses that you recognize as pain and is often combined with over-the-counter (OTC) pain medications like:

No interactions were found between cyclobenzaprine and Ibuprofen PMR. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

The best acute back pain cocktail: The combination of a muscle relaxant and an NSAID provided the most effective symptom relief at one week in a study of over 200 patients with their first episode of back pain. Muscle relaxants should only be used for one to three weeks.

• acetaminophen (Tylenol)
• anti-inflammatory NSAIDs like ibuprofen (Advil, Motrin) or naproxen (Aleve).

Official Answer. Yes, you can take cyclobenzaprine and Tylenol (acetaminophen) together. There are no known interactions between these medicines, however this doesn’t necessarily mean that no interaction exist.

No interactions were found between Flexeril and ibuprofen. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

No. Advil, when taken at the recommended dose, does not contain any ingredients that are likely to make you sleepy. The active ingredient in Advil is ibuprofen, an NSAID (non-steroidal anti-inflammatory drug) that is a pain reliever and fever reducer.

Key facts. Ibuprofen takes 20 to 30 minutes to work if you take it by mouth. It takes 1 to 2 days to work if you put it on your skin. Ibuprofen works by reducing hormones that cause pain and swelling in the body.

Take 600 mg (3 over-the-counter tablets) of ibuprofen (Advil, Motrin) every 6-8 hours for the first 2-3 days. These dosages apply to healthy average-sized adults. If you have pain that is not alleviated by ibuprofen, consider 600 mg of ibuprofen (Advil, Motrin) every 6 hours AND Tylenol 650 mg every 4 to 6 hours.

IBUPROFEN (eye BYOO proe fen) is a non-steroidal anti-inflammatory drug (NSAID). It is used for dental pain, fever, headaches or migraines, osteoarthritis, rheumatoid arthritis, or painful monthly periods. It can also relieve minor aches and pains caused by a cold, flu, or sore throat.

A: It can take up to 24 hours to completely rid your system of ibuprofen, even though its effects generally last about 4 to 6 hours. According to the prescribing information, the ibuprofen half-life is about two hours. In case of an ibuprofen overdose, call 911 or Poison Control at 800-222-1222.

Over-the-Counter Pain Meds & Driving Ability As a general rule, you can safely drive if you are taking over-the-counter NSAID pain medications (ibuprofen, aspirin, Tylenol, etc.). However, if you are taking these NSAIDs in conjunction with other meds or substances (alcohol or drugs), they may be unsafe.