Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells. Eur J Immunol.

IL-12 is produced primarily by macrophages, dendritic cells, and B lymphocytes and regulates activation, IFN-γ production, and cytotoxicity of T cells and NK cells.

The molecular components of these signal transduction pathways are always activated by a chemical signaling molecule. The first two classes are secreted molecules and thus can act on target cells removed from the site of signal synthesis or release. …

IL-12 can aid in the activation and regulation of several cytotoxic immune cells including macrophages, natural killer cells, and T cells, thus making it a ‘pro-inflammatory cytokine’.

Introduction: Interleukin 12 receptor beta 1 (IL12Rβ1) deficiency is a primary immunodeficiency resulting mainly in susceptibility to opportunistic infection by non-tuberculous, environmental mycobacteria and severe infection caused by Salmonella spp.

NK cells secrete large quantities of IFN-γ in response to Herceptin-coated human breast cancer cells and IL-12. (a) The MDA-468 and SKBR3 cell lines were cultured with purified NK cells in our in vitro coculture assay.

IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40).

IL-12 is a pleiotropic cytokine that plays an important role in innate and adaptive immunity. IL-12 induces T cell proliferation and IFN-gamma secretion from activated T cells. It was also reported that IL-12 prevents apoptosis of CD4(+) T cells.

Describes a series of chemical reactions in which a group of molecules in a cell work together to control a cell function, such as cell division or cell death.

Signal transduction pathways play a crucial role in a variety of cellular processes including self renewal and differentiation, proliferation, and cell death, and ultimately regulate the balance between regenerative potential and the risk of neoplastic transformation.

IL-12p40 (p40) is a subunit of the IL-12 family of cytokines, which associates with the p35 subunit to form IL-12p70 (IL-12) and with the p19 subunit to form IL-23. IL-12 is a well-known inducer of the Th1 response, and polymorphisms of the IL-23 receptor are negatively associated with the development of IBD.

Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity.

The p40 chain can pair with p35 or p19 to form IL-12 or IL-23, respectively, whereas Ebi3 can pair with p28 or p35 to form IL-27 or IL-35, respectively. The receptor chains are also used by multiple cytokines.

The heterodimeric cytokine IL-12 consists of a 35-kd light chain (p35 or IL-12A) and 40-kd heavy chain (p40 or IL-12B). In the following, we will mainly discuss IL-12 (interleukin 12) & receptor, IL-12 (interleukin 12) function and IL-12 (interleukin 12) signaling Pathway.

Interleukin (IL)-23 and IL-12 are closely related in structure, and these cytokines regulate both innate and adaptive immunity. However, the precise signaling networks that regulate the production of each in Toxoplasma gondii-infected THP-1 monocytic cells, particularly the PI3K/AKT and MAPK signali …

Despite similarities in the signaling pathways that they activate, cytokines belonging to the IL-12 family have distinct effects on the immune response. A number of these effects are brought about by the ability of the IL-12 family cytokines to differentially regulate the activities of specific T cell subsets.